Interhemispheric motor networks are abnormal in patients with Gilles de la Tourette syndrome
Identifieur interne : 001C20 ( Main/Exploration ); précédent : 001C19; suivant : 001C21Interhemispheric motor networks are abnormal in patients with Gilles de la Tourette syndrome
Auteurs : Tobias B Umer [Allemagne] ; Götz Thomalla [Allemagne] ; Johan Kroeger [Allemagne] ; Melanie Jonas [Allemagne] ; Christian Gerloff [Allemagne] ; Friedhelm Christoph Hummel [Allemagne] ; Kirsten Müller-Vahl [Allemagne] ; Alfons Schnitzler [Allemagne] ; Hartwig Roman Siebner [Danemark] ; Michael Orth [Allemagne] ; Alexander Münchau [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-12-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Anisotropy, Brain Mapping, Corpus Callosum (physiopathology), Corpus callosum, Diffusion Magnetic Resonance Imaging, Diffusion tensor imaging, Female, Gilles de la Tourette syndrome, Human, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Motor Cortex (physiopathology), Nerve Net (physiopathology), Nervous system diseases, Severity of Illness Index, Tic, Tourette Syndrome (physiopathology), Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, corpus callosum, diffusion tensor imaging, fractional anisotropy, interhemispheric inhibition, tic, transcranial magnetic stimulation.
- MESH :
Abstract
Brain imaging has shown altered corpus callosum (CC) morphology in patients with Gilles de la Tourette syndrome (GTS). Yet it is unclear whether these morphological changes are associated with altered interhemispheric interactions. Here, we combined transcranial magnetic stimulation (TMS) with diffusion tensor magnetic resonance imaging (DTI) to explore functional and structural interhemispheric connections between the left and right motor hand areas. We studied 14 unmedicated GTS patients without psychiatric comorbidity (2 women, mean age 35.5 years) and 15 healthy volunteers (3 women, mean age 35 years). Left‐to‐right and right‐to‐left interhemispheric inhibitions (IHIs) were measured in hand muscles with TMS. In 13 GTS patients and all healthy controls, we measured fractional anisotropy (FA) with DTI to examine the relation between functional measures of interhemispheric connectivity as derived by TMS and structural properties of the CC region that carries fibers interconnecting both motor cortices. In GTS patients, left‐to‐right IHI was weaker than right‐to‐left IHI. Left‐to‐right IHI in GTS patients was also reduced compared with healthy controls. Voxel‐based morphometric analysis revealed that FA in the motor region of the CC did not differ between groups. However, there was a significant interaction between groups and the relation between regional FA and left‐to‐right IHI in the motor region of the CC. A negative linear relation between FA and left‐to‐right IHI was present in control subjects but not in patients. Our combined TMS‐DTI approach demonstrates abnormal functional interhemispheric connectivity in GTS accompanied by an altered structure–function relationship in the motor CC. © 2010 Movement Disorder Society.
Url:
DOI: 10.1002/mds.23418
Affiliations:
- Allemagne, Danemark
- Bade-Wurtemberg, Basse-Saxe, District de Tübingen, Hambourg
- Hambourg, Hanovre, Ulm
- Université d'Ulm
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wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Neuroscience and Medical Psychology, Heinrich‐Heine University, Düsseldorf</wicri:regionArea><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Heinrich‐Heine University, 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Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Centre Hamburg‐Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-12-15">2010-12-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2828">2828</biblScope><biblScope unit="page" to="2837">2837</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">4726145F4CD67A06D751B9D2EE7139A6CF7264D4</idno><idno type="DOI">10.1002/mds.23418</idno><idno type="ArticleID">MDS23418</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anisotropy</term><term>Brain Mapping</term><term>Corpus Callosum (physiopathology)</term><term>Corpus callosum</term><term>Diffusion Magnetic Resonance Imaging</term><term>Diffusion tensor imaging</term><term>Female</term><term>Gilles de la Tourette syndrome</term><term>Human</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Nerve Net (physiopathology)</term><term>Nervous system diseases</term><term>Severity of Illness Index</term><term>Tic</term><term>Tourette Syndrome (physiopathology)</term><term>Transcranial Magnetic Stimulation</term><term>Transcranial magnetic stimulation</term><term>corpus callosum</term><term>diffusion tensor imaging</term><term>fractional anisotropy</term><term>interhemispheric inhibition</term><term>tic</term><term>transcranial magnetic stimulation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Corpus Callosum</term><term>Motor Cortex</term><term>Nerve Net</term><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Anisotropy</term><term>Brain Mapping</term><term>Diffusion Magnetic Resonance Imaging</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anisotropie</term><term>Corps calleux</term><term>Homme</term><term>Imagerie du tenseur de diffusion</term><term>Pathologie du système nerveux</term><term>Stimulation magnétique transcrânienne</term><term>Syndrome de Gilles de la Tourette</term><term>Tic</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Brain imaging has shown altered corpus callosum (CC) morphology in patients with Gilles de la Tourette syndrome (GTS). Yet it is unclear whether these morphological changes are associated with altered interhemispheric interactions. Here, we combined transcranial magnetic stimulation (TMS) with diffusion tensor magnetic resonance imaging (DTI) to explore functional and structural interhemispheric connections between the left and right motor hand areas. We studied 14 unmedicated GTS patients without psychiatric comorbidity (2 women, mean age 35.5 years) and 15 healthy volunteers (3 women, mean age 35 years). Left‐to‐right and right‐to‐left interhemispheric inhibitions (IHIs) were measured in hand muscles with TMS. In 13 GTS patients and all healthy controls, we measured fractional anisotropy (FA) with DTI to examine the relation between functional measures of interhemispheric connectivity as derived by TMS and structural properties of the CC region that carries fibers interconnecting both motor cortices. In GTS patients, left‐to‐right IHI was weaker than right‐to‐left IHI. Left‐to‐right IHI in GTS patients was also reduced compared with healthy controls. Voxel‐based morphometric analysis revealed that FA in the motor region of the CC did not differ between groups. However, there was a significant interaction between groups and the relation between regional FA and left‐to‐right IHI in the motor region of the CC. A negative linear relation between FA and left‐to‐right IHI was present in control subjects but not in patients. Our combined TMS‐DTI approach demonstrates abnormal functional interhemispheric connectivity in GTS accompanied by an altered structure–function relationship in the motor CC. © 2010 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Danemark</li></country><region><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>District de Tübingen</li><li>Hambourg</li></region><settlement><li>Hambourg</li><li>Hanovre</li><li>Ulm</li></settlement><orgName><li>Université d'Ulm</li></orgName></list><tree><country name="Allemagne"><region name="Hambourg"><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name></region><name sortKey="Gerloff, Christian" sort="Gerloff, Christian" uniqKey="Gerloff C" first="Christian" last="Gerloff">Christian Gerloff</name><name sortKey="Hummel, Friedhelm Christoph" sort="Hummel, Friedhelm Christoph" uniqKey="Hummel F" first="Friedhelm Christoph" last="Hummel">Friedhelm Christoph Hummel</name><name sortKey="Jonas, Melanie" sort="Jonas, Melanie" uniqKey="Jonas M" first="Melanie" last="Jonas">Melanie Jonas</name><name sortKey="Jonas, Melanie" sort="Jonas, Melanie" uniqKey="Jonas M" first="Melanie" last="Jonas">Melanie Jonas</name><name sortKey="Kroeger, Johan" sort="Kroeger, Johan" uniqKey="Kroeger J" first="Johan" last="Kroeger">Johan Kroeger</name><name sortKey="Muller Ahl, Kirsten" sort="Muller Ahl, Kirsten" uniqKey="Muller Ahl K" first="Kirsten" last="Müller-Vahl">Kirsten Müller-Vahl</name><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name></country><country name="Danemark"><noRegion><name sortKey="Siebner, Hartwig Roman" sort="Siebner, Hartwig Roman" uniqKey="Siebner H" first="Hartwig Roman" last="Siebner">Hartwig Roman Siebner</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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